2017. Two-step ATP-driven opening of cohesin head (1/3).
ATP hydrolysis at active site 1 of human cohesin in the presence of Rad21. Quantum Mechanics / Molecular Mechanics. The different steps in the reaction are highlighted: initial structure (S), stabilization of the catalytic water molecule, transition state (TS) and final product (P).
Published in: Scientific Reports 7, 3266. [
https://www.nature.com/articles/s4159...]
Two-step ATP-driven opening of cohesin head (1/3) severin
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